By W. Knoche (auth.), Professor Dr. Christian Bauer, Professor Dr. Gerolf Gros, Professor Dr. Heinz Bartels (eds.)

This quantity comprises the papers awarded on the symposium on Biophysics and body structure of Carbon Dioxide held at Regensburg, April 17-20, 1979. The manuscripts signify the complete or maybe a longer account of the oral shows. we've got made up our minds to not contain any a part of the discussions which happened after the lectures simply because this is able to have resulted in an undue growth of the already significant quantity. The symposium introduced jointly a few 60 scientists of assorted disciplines together with biophysicists, chemists, biochemists, physiologists, pharmacologists, in addition to clinicians whose examine actions are cen­ tered round the a variety of facets of the reactions and the regulatory position of CO in the physique. 2 In view of the truth that quite a few textbooks and complaints of Symposia deal expertly with the function of CO in acid-base stability, it 2 was once made up our minds to not comprise this point within the current symposium. This holds additionally for the biochemistry of carboxylation and decarboxylation reactions. specific emphasis was once put on the subsequent topics: (1) Chemical reactions of CO in water and facilitated diffusion of CO2 , 2 (2) CO adducts to proteins, specifically hemoglobin, and peptide 2 hormones, (3) constitution and serve as of carbonic anhydrase, (4) CO 2 trade and carbonic anhydrase job in breathing and nonrespi­ ratory platforms. every one part comprises at the very least one introductory paper that provides the present wisdom in a extra common framework.

Show description

Read or Download Biophysics and Physiology of Carbon Dioxide: Symposium Held at the University of Regensburg (FRG) April 17–20, 1979 PDF

Best biophysics books

Biopolymers at Interfaces, Second Edition (Surfactant Science Series)

This re-creation positive factors examine from approximately 60 of the profession's so much uncommon overseas professionals. spotting rising advancements in biopolymer platforms study with absolutely up-to-date and increased chapters, the second one variation discusses the biopolymer-based multilayer constructions and their software in biosensors, the growth made within the realizing of protein behaviour on the air-water interface, experimental findings in ellipsometry and reflectometry, and up to date advancements bearing on protein interfacial behaviour in microfabricated overall research structures and microarrays.

Recognition Receptors in Biosensors

This ebook provides an important and up to date assessment of assorted reputation receptors, their immobilization, and an outline of floor characterization options. exotic scientists from key associations around the globe have contributed chapters that supply a deep research in their specific topics; whilst, every one subject is framed in the context of this built-in method.

Extra resources for Biophysics and Physiology of Carbon Dioxide: Symposium Held at the University of Regensburg (FRG) April 17–20, 1979

Sample text

15. The difference between the curve obtained in a low p002 range and that obtained in a high pC0 2 range is a measure of the facilitation of CO 2 diffusion in the low pC02 range. c CO2 diffusion coefficients in solutions of human hemoglobin, measured in a low and a high p002 range, as a function of hemoglobin concentration. 15. , only one half of the measured proton flux can be explained by translational diffusion, and rotational diffusion appears to be important. 8 tfo, on the other hand, there is only a difference of 8% between postulated and translational diffusion coefficients.

When this protein molecule performs half a rotation about its axis perpendicular to the plane of the figure, the buffering group becomes exposed to a more alkaline pH, the proton may dissociate and will then be accepted by protein molecule 2. The chemical reaction that takes place is a proton exchange between two protein molecules and is shown in the lower part of Fig. ' By successively repeated steps of chemical reaction and protein rotation, a facilitated flux of protons across a layer of protein solution is established.

We therefore derived an equation that describes facilitated proton transport by rotational diffusion, and we measured the rotational diffusion coefficient of earthworm hemoglobin. Proton flux by rotational diffusion of a spherical protein is given by Gros (1976) and Gros et al. (I 980): (8) where r is the molecular radius of the protein, and E> its rotational diffusion coefficient. The total proton flux mediated by translation and rotation is then given by the sum of Eqs. (3) and (8): F (D H+ = trans 1T r 2 + "4 n) '"' [Prot] {3 dPdxH , (9) or, using an apparent transport coefficient, Drot + trans' that describes the effects of rotation as well as translation, we can write: [P] dpH F H + = D rot + trans rot {3 dX (10) We now obtained a direct estimate of D rot + trans in the following manner.

Download PDF sample

Download Biophysics and Physiology of Carbon Dioxide: Symposium Held by W. Knoche (auth.), Professor Dr. Christian Bauer, Professor PDF
Rated 4.49 of 5 – based on 39 votes