By Patricia M. Dove, James J. De Yoreo, Steve Weiner

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W. H. Schlesinger, Elsevier Science. 8: (in press) Spiro BF (1971) Diagenesis of some scleractinian corals from the Gulf of Elat, Israel. Bull Geol Soc Denmark 21:1-10 Stumm W (1992) Chemistry of the Solid-Water Interface. John Wiley & Sons Inc, New York Sumper M (2002) A phase separation model for the nanopatterning of diatom biosilica. Science 295:24302433 Swift DM, Wheeler AP (1991) Some structural and functional properties of a possible organic matrix from the frustules of the freshwater diatom Cyclotella meneghiniana.

Molecular Manufacturing will describe the major biomineralizationrelated macromolecules and how they are created and exported for use in biomineral formation. Molecular Performance will present structural concepts of cell-generated macromolecules which function in the biomineralization process. Finally, in Molecular Manipulation, we will briefly review contemporary techniques in molecular biology and chemical synthesis that may be mentioned in other chapters of this Review. The reader should be aware that no single chapter or overview can cover all of the relevant information regarding cellular biology, molecular biology, and biochemistry, the three disciplines which outline not only the structure and function of cells and macromolecules, but also the biomineralization process itself.

Ann Inst Oceanogr Monaco 31:1-36 Hemleben C, Anderson OR, Berthold W, Spindler M (1986) Calcification and chamber formation in foraminifera-a brief overview. In: Biomineralization in Lower Plants and Animals. Leadbeater BSC, Riding R (eds) Clarendon Press, Oxford, p 237-249 Iler RK (1979) The Chemistry of Silica. John Wiley & Sons, New York Ip YK, Lim ALL, Lim RWL (1991) Some properties of calcium-activated adenosine triphosphatase from the hermatypic coral Galaxea fascicularis. Mar Biol 111:191-197 Kingsley R, Watabe N (1987) Role of carbonic anhydrase in calcification in the gorgonian Leptogorgia virgulata (Lamarck) (Coelenterata: Gorgonacea).

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