By Jürgen Angerer

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52, 6248–6253 (1992). , Hengstler, J. : Multiplex polymerase chain reaction protocol for the simultaneous analysis of the glutathione S-transferase GSTM1 and GSTT1 Polymorphisms, Anal. Biochem. 236, 184–186 (1996). , Petruzzelli, S. : Possible prognostic value of pulmonary Ah-locus-linked enzymes in patients with tobacco-related lung cancer, Int. J. Cancer, 46, 185–188 (1990). : The role of individual susceptibility in cancer burden related to environmental exposure, Environ. Hlth. Perspect, 104 (S3), 569–577 (1996).

The prevalence of cataracts correlates with the increase of TNT-Hb adducts. No cataracts were found when the TNT-Hb level was below 30 ng/g Hb (determined by ELISA), even for individuals who had been employed for up to 20 years in this factory. The three subjects with the highest level of adducts i300 ng/g Hb were all diagnosed with cataracts. Possibly similar protein adducts of TNT occur with lens proteins of exposed workers. This is subject of a future study. 27 28 Scheme 2. Innere Belastung und Hämoglobin-Addukte Scheme 1.

Poirier, M. , Beland, F. : Aromatic amine DNA adduct formation in chronically-exposed mice: considerations for human comparison, Mutat. , 376, 177–184 (1997). : Biomonitoring of arylamines: haemoglobin adducts of aniline derivatives, J. Chromatog. , 667, 75–83 (1995). : Hemoglobin binding of bicyclic aromatic amines, Chem. Res. Toxicol. 11, 471–483 (1998). : Comparison of hemoglobin binding, mutagenicity and carcinogenicity of arylamines and nitroarenes, Chimia, 49, 374-380 (1995), and 53, 456 (1999).

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