By Mary Ann Dudko, Margie Larsen, Bill Langley
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Adoption Studies The optimal study paradigm for discriminating the role of genetic and environmental factors and their interaction in the development of a disorder is the cross-fostering study in which (1) adoptees with biologic vulnerability are reared in homes of non-drug abusing adoptive parents and (2) adoptees who lack a parental history of substance abuse are reared in homes of parents with substance abuse. Such studies can determine the effects of biologic vulnerability and environmental exposure to substance abuse and their mutual influence in the risk of substance abuse.
However, increasing evidence reveals that environmental risk factors may either potentiate or protect against expression of underlying genetic and biological vulnerability factors. Furthermore, despite their history of independence, the fields of epidemiology and genetics share much common ground. Both are interested in determining the etiology of complex human disorders and predicting familial recurrence risks for such disorders. Synthesis of genetics and epidemiology is essential to understand the complex etiology of most human diseases.
In both types of studies, observations can be made regarding time-space clustering of disease, which can provide information regarding imvironmental agents, or a characteristic age of onset and course, which may provide information on genetic factors. Application of the genetic-epidemiologic approach has yielded information on risk and etiologic factors for a number of disorders such as diabetes, hyperlipidemia, and coronary heart disease (King, Lee, Spinner, Thomson, & Wrensch, 1984). Genetic epidemiology is one of the most powerful approaches for gaining understanding of the causes of psychopathology.