By Walther Rathenau

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1998; Parfitt, 2000a, 2000b, 2001; Schaffler, 2000). The band of proliferating mesenchymal cells advancing along the tunnel wall throw off preosteoblasts that dismantle their mitogenic machinery and become osteoblasts which start depositing layers or lamellae of bone around the tunnel walls. Unlike their progenitors, the new osteoblasts stay in place to lay down concentric 15-mm thick strips of bone around the tunnel wall while the proliferating progenitors move on behind the osteoclasts throwing off new bands of osteoblasts as they go.

This is hopefully all very interesting, but where do the osteoblasts come from to make a new Haversian canal surrounded by concentric layers of bone? B. , 1998; Parfitt, 2000a, 2000b, 2001; Schaffler, 2000). The band of proliferating mesenchymal cells advancing along the tunnel wall throw off preosteoblasts that dismantle their mitogenic machinery and become osteoblasts which start depositing layers or lamellae of bone around the tunnel walls. Unlike their progenitors, the new osteoblasts stay in place to lay down concentric 15-mm thick strips of bone around the tunnel wall while the proliferating progenitors move on behind the osteoclasts throwing off new bands of osteoblasts as they go.

6) which will travel through the canaliculi to the osteoblastic bone-lining cells with their array of glutamate receptors (Fig. , 2005). The signals from these receptors will contribute to their releasing of the SOST brakes on the reversion of the bone-lining cells to bone-making osteoblasts. K. you may say, but what has all of this to do with “CALLING THE DIGGERS”, the title of this section? While a strain-induced glutamate surge from osteocytes stimulates osteoblast generation it also stimulates osteoclast generation via the baby osteoclasts’ wet nurses— immature bone marrow osteoblastic cells (Atkins et al.

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